Easyhaler^® product family

PRESENTATIONS:
Budesonide and formoterol fumarate
dihydrate 80/4.5mcg, 160/4.5mcg and
320/9mcg per dose.

STRENGTHS (ACTUATIONS), PRICE:
80/4.5 mcg (120), £21.50
160/4.5 mcg (60), £10.75
160/4.5 mcg (120), £21.50
320/9 mcg (60), £21.50

AGE AND INDICATIONS: ASTHMA

Fobumix Easyhaler^® is indicated for the regular treatment of asthma where use of a combination (inhaled corticosteroid and long-acting β₂-adrenoceptor agonist) is appropriate: patients not adequately controlled with inhaled corticosteroids and “as needed” inhaled short-acting β₂-adrenoceptor agonists or patients already adequately controlled on both inhaled corticosteroids and long-acting β₂-adrenoceptor agonists.

Fobumix Easyhaler^® 80/4.5 is indicated for maintenance therapy in patients ≥6 years of age, and maintenance and reliever therapy (MART) in patients ≥12 years of age.

Fobumix Easyhaler^® 160/4.5 is indicated for reliever therapy (as needed, AIR), maintenance therapy and MART in patients ≥12 years of age.

Fobumix Easyhaler^® 320/9 is indicated for maintenance therapy only in patients ≥12 years of age.

Note: Fobumix Easyhaler^® 80 micrograms/ 4.5 micrograms is not appropriate in patients with severe asthma.

COPD (160/4.5mcg & 320/9mcg only):
Symptomatic treatment of adults (18 years and older) with COPD with FEV₁ < 70% predicted normal (post-bronchodilator) and an exacerbation history despite regular bronchodilator therapy.

CONTRAINDICATIONS:
Fobumix Easyhaler^® is contraindicated in patients with hypersensitivity to budesonide, formoterol fumarate dihydrate, lactose or milk proteins.

UNDESIRABLE EFFECTS:
Since Fobumix Easyhaler^® contains both budesonide and formoterol, the same pattern of undesirable effects as reported for these substances may occur.

No increased incidence of adverse reactions has been seen following concurrent administration of the two compounds. The most common drug related adverse reactions are pharmacologically predictable side-effects of ß₂ agonist therapy, such as tremor and palpitations. These tend to be mild and usually disappear within a few days of treatment.

ADVERSE EVENTS:
Common: Candida infections in the oropharynx, Headache, tremor, Palpitations, Mild irritation in the throat, coughing, dysphonia including hoarseness. 160/4.5 mcg & 320/9 mcg strengths: pneumonia (in COPD patients).

PRESENTATIONS:
Salmeterol/fluticasone propionate 50/250mcg and 50/500mcg per dose.

AGE:
Adults and adolescents 12 years and older

STRENGTHS (ACTUATIONS), PRICE:
50/250 mcg (60), £21.50
50/500 mcg (60), £26.99

INDICATION:
Asthma all strengths: Indicated in adults and adolescents 12 years and older. Regular treatment of asthma where use of a combination product (long-acting ß₂ agonist and inhaled corticosteroid) is appropriate:

patients not adequately controlled with
inhaled corticosteroids and ‘as needed’
inhaled short-acting ß₂ agonist

or

patients already adequately controlled
on both inhaled corticosteroid and long
acting-beta-₂ agonist.

COPD: (50/500mcg only):
Symptomatic treatment of patients with COPD, with a FEV₁<60% predicted normal (pre-bronchodilator) and a history of repeated exacerbations, who have significant symptoms despite regular bronchodilator therapy.

CONTRAINDICATIONS:
Fusacomb Easyhaler is contraindicated in patients with hypersensitivity to salmeterol, fluticasone propionate, lactose or milk proteins.

UNDESIRABLE EFFECTS:
As Fusacomb Easyhaler contains salmeterol and fluticasone propionate, the type and severity of adverse reactions associated with each of the compounds may be expected. There is no incidence of additional adverse events following concurrent administration of the two compounds.

ADVERSE EVENTS:
Very common: Nasopharyngitis, headaches.
Common: Candidiasis of the mouth and throat, Pneumonia (in COPD patients), Bronchitis, Hypokalaemia, Throat irritation, hoarseness/dysphonia, Sinusitis, Contusions, Muscle cramps, Traumatic fractures, Arthralgia, Myalgia.

Prescribers should consult the SmPC in relation to other side effects.

PRESENTATIONS:
Salbutamol 100mcg and 200mcg per dose.

AGE:
Adults and children aged 4 years and over

STRENGTHS (ACTUATIONS), PRICE:
100 mcg (200), £3.31
200 mcg (200), £6.63

INDICATION:
Symptomatic treatment of asthma attacks and exacerbations of asthma in adults and children aged 4 years and over; prevention of exercise-induced bronchospasm or before unavoidable allergen exposure; symptomatic treatment of broncho-asthma and other conditions associated with reversible airways obstruction.

CONTRAINDICATIONS:
Easyhaler Salbutamol is contraindicated in patients with hypersensitivity to salbutamol, lactose or milk proteins. Not for management of premature labour or threatened abortion.

UNDESIRABLE EFFECTS:
The undesirable effects caused by normally used inhaled doses of salbutamol are mild, typical for sympathomimetic agents, and they usually disappear with continued treatment.

ADVERSE EVENTS:
Common: Tremors, palpitations, peripheral vasodilatation, and as a result small increase in heart rate

Prescribers should consult the SmPC in relation to other side effects.

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PRESENTATIONS: Formoterol fumarate dihydrate 12 mcg per dose. AGE: Adults and children aged 6 years and over. STRENGTHS (ACTUATIONS), PRICE: 12 mcg (120), £23.75 INDICATION: Treatment of asthma in patients treated with inhaled corticosteroids and who also require a long-acting ß2-agonist; relief of reversible airways obstruction in patients with obstruction in adult patients with COPD needing long-term bronchodilators.		CONTRAINDICATIONS: Formoterol Easyhaler is contraindicated in patients with hypersensitivity to formoterol, lactose or milk proteins. UNDESIRABLE EFFECTS: The most commonly reported adverse events of ß2-agonist therapy, such as tremor and palpitations, tend to be mild and disappear within a few days of treatment. ADVERSE EFFECTS: Common: Headache, tremor, palpitations. Prescribers should consult the SmPC in relation to other side effects.
​ ​ PRESENTATIONS: Budesonide 100 mcg, 200 mcg and 400 mcg per dose AGE: Adults and children aged 6 years and over. STRENGTHS (ACTUATIONS), PRICE: 100 mcg (200), £8.86 200 mcg (200), £17.71 400 mcg (100), £17.71   INDICATION: Treatment of mild, moderate or severe persistent asthma. CONTRAINDICATIONS: Easyhaler Budesonide is contraindicated in patients with hypersensitivity to budesonide, lactose or milk proteins. ADVERSE EVENTS: Common: Oropharyngeal candidiasis, cough, throat irritation, difficulty in swallowing. Prescribers should consult the SmPC in relation to other side effects Read more about Easyhaler Budesonide here. ​ ​ PRESENTATIONS: Beclometasone 200 mcg per dose. AGE: Adults only (not indicated for use in children). STRENGTHS (ACTUATIONS), PRICE: 200 mcg (200), £14.93 INDICATION: Prophylactic management of mild, moderate, or severe asthma in adults.   CONTRAINDICATIONS: Easyhaler Beclometasone is contraindicated in patients with hypersensitivity to beclometasone, lactose or milk proteins. Special care in patients with active or quiescent pulmonary tuberculosis. ADVERSE EVENTS: Very common: Candidiasis of the mouth and throat. Common: Hoarseness/throat irritation, cough. Prescribers should consult the SmPC in relation to other side effects.